EXTRA EXTRA The newest studies (July, 21st) show that Ivermectin is extraordinarily effective in the prevention and eradication of Covid-19 EXTRA EXTRA
Ivermectin is very safe. It is has been used effectively for many years to kill various parasites in humans and animals. The dose is 3mg twice a day for five days.
I know it . It has stopped covidin it's tracks four times for me since the pandemic started many front liners use it more than 60 mg a day can cause neurotoxicity so be careful. Thanks Dr mark
The trees burning is putting a lot of bomb detonations, chernobyl, fukushima and all the other meltdowns and radioactive ☢️ shit they lie, about back into the air we breath, the food we eat , the water we drink. It is also making climate change much worse. There are only 5 years left for humans on earth
FDA, CDC and manufacturer of Ivermectin have issued warnings about "humans"using this "horse de-wormer" for Covid 19! How insane that Dr. Mark is hawking the FOX NEWS "miracle cure"? We,, now we know why for him "Spring always turns to Winter"! Rational people know Summer follows Spring, and Nichiren claimed that those who believe in the Lotus Sutra may feel as though they are in Winter... but with continued faith and practice, "Winter ALWAYS turns to Spring".
Looks like you are a classic case of head split in 7 pieces Dr. Mark!
The surgeon general issued a warning about Ivermectin- As a physician, you should know that there are no peer reviewed article; few studies that were done have notable flaws per NIH web site. I notice you did not emphasize the importance of consulting with one's doctor, being under a doctor's care and supervision. You have also boasted about holding group "chanting sessions" in your home, claiming "protection" based on your religious beliefs. Your blog has become another internet disinformation site. Worse because Buddhism is based on "reason" not evangelical zealotry and "following persons". There is something very odd about your claims of "superiority"/ arrogance.
I'd say Dr mark, has a pretty good handle on the good and bad of the fda . Years of medical practice. The fda also approves of gamma knives and, cesium 137 salting of prostates . It approves of shitty radiation therapy, that destroys bone marrow in cancer patients, that are already half dead. It approve of iodine 131 injections to ablate thyroids. You are out of your league dude
Even if ivermectin were completely ineffective, a low dose of 3mg bid is as safe as 3 to 6 aspiring daily for 5 days. Not that I wish on you Sars pulmonary disease but if you were gasping for breath, regeneron and bipap having failed, you would be begging for alternative medicine. You are a phony in store for a great awakening.
"First, do no harm"- all pharmaceuticals are poisons essentially- . Ethical physicians do not recommend non approved medications on the internet-- to people that are not under their care. CDC guidelines : Get (now fully approved by FDA) Covid 19 vaccination; wear masks in public place; socially distance, practice regular/thorough hand hygiene. AND do not fall for "quack remedies". I will add that Buddhism is based on reason, following Nichiren and practicing faith (chanting) the Mystic Law. "Persons" who assert superiority, ignoring reason and failing to adhere to prudent behavior that shows the utmost respect for the well being of others, cannot be called, wise physicians much less Nichiren Buddhists.
Ivermectin in COVID-19: What do we know? https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7521351/
Diabetes & Metabolic Syndrome Elsevier Ivermectin in COVID-19: What do we know? Sanjay Pandey, Subodh Kumar Pathak, [...], and Harish V.K. Ratna
Additional article information
Dear editor
Ivermectin is a drug of a wide range of bioactivity and has been in use for more than 30 years for treatment of parasitic infections in humans [1].It is being considered as the possible target drug for SARS CoV-2 and is under extensive research in clinical trials [2].Ivermectin is used in a dose of 0.15 mg/kg–0.2 mg/kg body weight for most of the parasitic infestations as oral tablet and is well tolerated. This is not the first time when the antiviral properties of ivermectin has been tested against human virus. Ivermectin has shown its potent in vitro antiviral effects against several RNA viruses, such as Zika virus, Influenza A virus, Newcastle disease virus, Chikungunya virus, Yellow fever virus, Dengue virus, Japanese encephalitis virus and DNA virus such as BK polyomavirus and Equine herpesvirus type 1 [3].
The anti-SARS-CoV-2 of ivermectin is likely through inhibition of viral IMPα/β1-mediated nuclear import, which reduces the replication of virus and thereby the viral load [4].Caly et al. showed the in vitro benefit of ivermectin in Vero-hSLAM cells infected with SARS-CoV-2.The authors found that a single dose of ivermectin was able to effect ∼5000-fold reduction in viral RNA at 48 h [4]. In a preprint article, authors used molecular docking and molecular dynamics simulation approach to explore the mechanism of action of ivermectin and doxycycline on inhibition of SARS-CoV-2 and reveled that combination of ivermectin and doxycycline might be executing the effect by inhibition of viral entry and enhance viral load clearance by targeting various viral functional proteins. The authors also concluded that both ivermectin and doxycycline have significantly bind with SARS-CoV-2 proteins but ivermectin had better binding properties than doxycycline [5].However a contradictory pharmacokinetic report states that with the routine antiparasitic dose of ivermectin,its inhibitory action on SARS-CoV-2 concentrations are practically not attainable in humans [6].
Recently, two in vivo studies of ivermectin alone or in combination with doxycycline has been published. In a Randomized Trial of 116 patients treated with Ivermectin-Doxycycline(n = 60) or Hydroxychloroquine-Azithromycin(n = 56) therapy the authors found Ivermectin-Doxycycline combination therapy had a better success of symptomatic relief; shortened recovery duration, reduced adverse effects, and superior patient compliance compared to the Hydroxychloroquine-Azithromycin combination. The authors concluded ivermectin as a better choice for the treatment of patients with mild to moderate COVID-19 disease [7].In a retrospective study of 280 patients with SARS-CoV-2 infection treated with ivermectin (n = 173) or standard of care(n = 107) the authors found lower mortality in the ivermectin group (25.2% versus 15.0%, OR 0.52, 95% CI 0.29–0.96). The authors also reported lower mortality among patients with severe pulmonary disease (n = 75) treated with
ivermectin (38.8% vs 80.7%, OR 0.15, CI 0.05–0.47, P = .001), however no significant difference was found in successful extubation rates (36.1% vs 15.4%, OR 3.11 (0.88–11.00), p = .07) [8].
We searched the various trial registries to find out the ongoing trials of ivermectin in COVID 19.In the European Union Clinical Trials Register, we found 5 clinical trials of ivermectin in SARS-CoV-2 infection(2020-001994-66, 2020-001971-33, 2020-002091-12, 2020-001474-29, 2020-002283-32) [9].According to government portal Clinical Trials Registry India (CTRI), ivermectin is part of at least five ongoing trials in the country [10]. At the latest, the US clinical trials registry has 38 clinical trials from different countries in different stages of completion [11]. Current clinical trials have used ivermectin in a dose ranging from 200 to 1200 mcg/kg body weight, for a duration of 3–7 days, which is showing promising results both in terms of symptomatology as well as viral load reduction [10].
Ivermectin is more cost effective as compared to hydroxychloroquine and azithromycin combination. The overall cost effectiveness, safety profile makes it more lucrative candidate for clinical trials. However, the safety of ivermectin at higher doses, in children less than 15 kg and pregnant women has insufficient evidence and hence is not recommended in these population groups [12]. With the fear of the disease among the population, herd mentality continues in India and social media is still dominated by how to take these drugs and inquiry about their doses continue among the crowd [13]. One such news of ICMR including ivermectin in treatment guidelines for COVID-19 circulated over the social media leading to a heavy over the counter sale of the drug in a short span. As a fact check the Indian Council of Medical Research (ICMR) is still reviewing the benefits of ivermectin and doxycycline as a potential therapy for COVID-19 and no such treatment guidelines is available on the website [14,15]. On April 10, 2020, FDA issued a statement concerning self-administration of ivermectin against COVID-19 referring to recently published in vitro study [4].
The clinical efficacy and utility of ivermectin in SARS CoV-2 infected patients are unpredictable at this stage, as we are dealing with a completely novel virus. However, repurposing existing drugs as possible COVID-19 treatment is astute usage of existing resources, and we await results of well-designed large scale randomized controlled clinical trials exploring treatment efficacy of ivermectin to treat SARS-CoV-2.
Declaration of competing interest On the behalf of all the authors in paper, I corresponding author hereby accept that there are no conflicts of interest.
Article information Diabetes Metab Syndr. 2020 November-December; 14(6): 1921–1922. Published online 2020 Sep 28. doi: 10.1016/j.dsx.2020.09.027 PMCID: PMC7521351 PMID: 33032231 Sanjay Pandey,c Subodh Kumar Pathak,a,∗ Apurva Pandey,b Abhijeet Ashok Salunke,d Jasneet Chawla,a Aryan Sharma,a Sarthak Sharma,a Praveen Thivari,a and Harish V.K. Ratnaa aDepartment of Orthopaedics, MMIMSR, MM Deemed to be University, Ambala, Haryana, India bDepartment of Radiation Oncology, MMIMSR, MM Deemed to be University, Ambala, Haryana, India cChandramohan Hospital,
I know it . It has stopped covidin it's tracks four times for me since the pandemic started many front liners use it more than 60 mg a day can cause neurotoxicity so be careful. Thanks Dr mark
ReplyDeleteSeems that the low dose works well
ReplyDeleteThe trees burning is putting a lot of bomb detonations, chernobyl, fukushima and all the other meltdowns and radioactive ☢️ shit they lie, about back into the air we breath, the food we eat , the water we drink. It is also making climate change much worse. There are only 5 years left for humans on earth
ReplyDeleteFDA, CDC and manufacturer of Ivermectin have issued warnings about
Delete"humans"using this "horse de-wormer" for Covid 19!
How insane that Dr. Mark is hawking the FOX NEWS "miracle cure"?
We,, now we know why for him "Spring always turns to Winter"!
Rational people know Summer follows Spring, and Nichiren claimed that those who believe in the Lotus Sutra may feel as though they are in Winter... but with continued faith and practice, "Winter ALWAYS turns to Spring".
Looks like you are a classic case of head split in 7 pieces Dr. Mark!
I see, you know more than The American Journal of Therapeautics. It seems as though it is YOU whose head is broken into seven pieces.
ReplyDeletehttps://www.cnn.com/videos/health/2021/08/22/ivermectin-mississippi-poison-control-calls-surgeon-general-murthy-reaction-keilar-sotu-vpx.cnn/video/playlists/coronavirus/
DeleteThe surgeon general issued a warning about Ivermectin-
As a physician, you should know that there are no peer reviewed article; few studies that were done have notable flaws per NIH web site. I notice you did not emphasize the importance of consulting with one's doctor, being under a doctor's care and supervision. You have also boasted about holding group "chanting sessions" in your home, claiming "protection" based on your religious beliefs.
Your blog has become another internet disinformation site. Worse because Buddhism is based on "reason" not evangelical zealotry and "following persons". There is something very odd about your claims of "superiority"/ arrogance.
I'd say Dr mark, has a pretty good handle on the good and bad of the fda . Years of medical practice. The fda also approves of gamma knives and, cesium 137 salting of prostates . It approves of shitty radiation therapy, that destroys bone marrow in cancer patients, that are already half dead. It approve of iodine 131 injections to ablate thyroids. You are out of your league dude
ReplyDeleteEven if ivermectin were completely ineffective, a low dose of 3mg bid is as safe as 3 to 6 aspiring daily for 5 days. Not that I wish on you Sars pulmonary disease but if you were gasping for breath, regeneron and bipap having failed, you would be begging for alternative medicine. You are a phony in store for a great awakening.
ReplyDeletehttps://www.cnn.com/videos/media/2021/08/24/coronavirus-ivermectin-false-claims-right-wing-media-foreman-ebof-pkg-vpx.cnn/video/playlists/coronavirus/
Delete"First, do no harm"- all pharmaceuticals are poisons essentially- . Ethical physicians do not recommend non approved medications on the internet-- to people that are not under their care.
CDC guidelines : Get (now fully approved by FDA) Covid 19 vaccination; wear masks in public place; socially distance, practice regular/thorough hand hygiene. AND do not fall for "quack remedies".
I will add that Buddhism is based on reason, following Nichiren and practicing faith (chanting) the Mystic Law.
"Persons" who assert superiority, ignoring reason and failing to adhere to prudent behavior that shows the utmost respect for the well being of others, cannot be called, wise physicians much less Nichiren Buddhists.
This comment has been removed by a blog administrator.
DeleteGReen looks like a baboon
ReplyDeletehttps://www.independent.co.uk/news/world/americas/us-politics/marjorie-taylor-greene-laugh-covid-b1887635.html
Ivermectin in COVID-19: What do we know?
ReplyDeletehttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7521351/
Diabetes & Metabolic Syndrome
Elsevier
Ivermectin in COVID-19: What do we know?
Sanjay Pandey, Subodh Kumar Pathak, [...], and Harish V.K. Ratna
Additional article information
Dear editor
Ivermectin is a drug of a wide range of bioactivity and has been in use for more than 30 years for treatment of parasitic infections in humans [1].It is being considered as the possible target drug for SARS CoV-2 and is under extensive research in clinical trials [2].Ivermectin is used in a dose of 0.15 mg/kg–0.2 mg/kg body weight for most of the parasitic infestations as oral tablet and is well tolerated. This is not the first time when the antiviral properties of ivermectin has been tested against human virus. Ivermectin has shown its potent in vitro antiviral effects against several RNA viruses, such as Zika virus, Influenza A virus, Newcastle disease virus, Chikungunya virus, Yellow fever virus, Dengue virus, Japanese encephalitis virus and DNA virus such as BK polyomavirus and Equine herpesvirus type 1 [3].
The anti-SARS-CoV-2 of ivermectin is likely through inhibition of viral IMPα/β1-mediated nuclear import, which reduces the replication of virus and thereby the viral load [4].Caly et al. showed the in vitro benefit of ivermectin in Vero-hSLAM cells infected with SARS-CoV-2.The authors found that a single dose of ivermectin was able to effect ∼5000-fold reduction in viral RNA at 48 h [4]. In a preprint article, authors used molecular docking and molecular dynamics simulation approach to explore the mechanism of action of ivermectin and doxycycline on inhibition of SARS-CoV-2 and reveled that combination of ivermectin and doxycycline might be executing the effect by inhibition of viral entry and enhance viral load clearance by targeting various viral functional proteins. The authors also concluded that both ivermectin and doxycycline have significantly bind with SARS-CoV-2 proteins but ivermectin had better binding properties than doxycycline [5].However a contradictory pharmacokinetic report states that with the routine antiparasitic dose of ivermectin,its inhibitory action on SARS-CoV-2 concentrations are practically not attainable in humans [6].
ReplyDeleteRecently, two in vivo studies of ivermectin alone or in combination with doxycycline has been published. In a Randomized Trial of 116 patients treated with Ivermectin-Doxycycline(n = 60) or Hydroxychloroquine-Azithromycin(n = 56) therapy the authors found Ivermectin-Doxycycline combination therapy had a better success of symptomatic relief; shortened recovery duration, reduced adverse effects, and superior patient compliance compared to the Hydroxychloroquine-Azithromycin combination. The authors concluded ivermectin as a better choice for the treatment of patients with mild to moderate COVID-19 disease [7].In a retrospective study of 280 patients with SARS-CoV-2 infection treated with ivermectin (n = 173) or standard of care(n = 107) the authors found lower mortality in the ivermectin group (25.2% versus 15.0%, OR 0.52, 95% CI 0.29–0.96). The authors also reported lower mortality among patients with severe pulmonary disease (n = 75) treated with
Deleteivermectin (38.8% vs 80.7%, OR 0.15, CI 0.05–0.47, P = .001), however no significant difference was found in successful extubation rates (36.1% vs 15.4%, OR 3.11 (0.88–11.00), p = .07) [8].
DeleteWe searched the various trial registries to find out the ongoing trials of ivermectin in COVID 19.In the European Union Clinical Trials Register, we found 5 clinical trials of ivermectin in SARS-CoV-2 infection(2020-001994-66, 2020-001971-33, 2020-002091-12, 2020-001474-29, 2020-002283-32) [9].According to government portal Clinical Trials Registry India (CTRI), ivermectin is part of at least five ongoing trials in the country [10]. At the latest, the US clinical trials registry has 38 clinical trials from different countries in different stages of completion [11]. Current clinical trials have used ivermectin in a dose ranging from 200 to 1200 mcg/kg body weight, for a duration of 3–7 days, which is showing promising results both in terms of symptomatology as well as viral load reduction [10].
Ivermectin is more cost effective as compared to hydroxychloroquine and azithromycin combination. The overall cost effectiveness, safety profile makes it more lucrative candidate for clinical trials. However, the safety of ivermectin at higher doses, in children less than 15 kg and pregnant women has insufficient evidence and hence is not recommended in these population groups [12]. With the fear of the disease among the population, herd mentality continues in India and social media is still dominated by how to take these drugs and inquiry about their doses continue among the crowd [13]. One such news of ICMR including ivermectin in treatment guidelines for COVID-19 circulated over the social media leading to a heavy over the counter sale of the drug in a short span. As a fact check the Indian Council of Medical Research (ICMR) is still reviewing the benefits of ivermectin and doxycycline as a potential therapy for COVID-19 and no such treatment guidelines is available on the website [14,15]. On April 10, 2020, FDA issued a statement concerning self-administration of ivermectin against COVID-19 referring to recently published in vitro study [4].
The clinical efficacy and utility of ivermectin in SARS CoV-2 infected patients are unpredictable at this stage, as we are dealing with a completely novel virus. However, repurposing existing drugs as possible COVID-19 treatment is astute usage of existing resources, and we await results of well-designed large scale randomized controlled clinical trials exploring treatment efficacy of ivermectin to treat SARS-CoV-2.
Declaration of competing interest
On the behalf of all the authors in paper, I corresponding author hereby accept that there are no conflicts of interest.
Article information
Diabetes Metab Syndr. 2020 November-December; 14(6): 1921–1922.
Published online 2020 Sep 28. doi: 10.1016/j.dsx.2020.09.027
PMCID: PMC7521351
PMID: 33032231
Sanjay Pandey,c Subodh Kumar Pathak,a,∗ Apurva Pandey,b Abhijeet Ashok Salunke,d Jasneet Chawla,a Aryan Sharma,a Sarthak Sharma,a Praveen Thivari,a and Harish V.K. Ratnaa
aDepartment of Orthopaedics, MMIMSR, MM Deemed to be University, Ambala, Haryana, India
bDepartment of Radiation Oncology, MMIMSR, MM Deemed to be University, Ambala, Haryana, India
cChandramohan Hospital,
I did the vaccines. I can't afford to get covid
ReplyDelete